Preheat your oven to 375°F (190°C). Grease a 9x13-inch baking dish or similar size.
Bring a large pot of salted water to a boil. Add the pasta and cook until just al dente according to package instructions. Drain and set aside.
In a large saucepan, melt the butter over medium heat. Add the flour and whisk constantly for about 2 minutes until the mixture is bubbly and slightly golden.
Gradually whisk in the milk, continuing to whisk until the mixture is smooth and starts to thicken, about 5 minutes.
Reduce the heat to low and add the cheddar, Gruyère, and mozzarella cheeses, stirring until melted and smooth.
Stir in the mustard powder, salt, and pepper
Add the cooked pasta to the cheese sauce, stirring gently to combine until all the pasta is well-coated.
In a small bowl, combine the panko breadcrumbs with the melted butter and Parmesan cheese, mixing until the breadcrumbs are evenly coated.
Transfer the macaroni and cheese mixture to the prepared baking dish. Sprinkle the breadcrumb topping evenly over the top.
Bake in the preheated oven for 25-30 minutes, or until the top is golden brown and the sauce is bubbling around the edges.
Let the mac and cheese cool for a few minutes before serving. Enjoy it hot and creamy, with the perfect balance of a crispy topping and a gooey center.